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Novel EPC1 gene fusions in endometrial stromal sarcoma.
Dickson, Brendan C; Lum, Amy; Swanson, David; Bernardini, Marcus Q; Colgan, Terrence J; Shaw, Patricia A; Yip, Stephen; Lee, Cheng-Han.
Afiliação
  • Dickson BC; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.
  • Lum A; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Swanson D; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada.
  • Bernardini MQ; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Colgan TJ; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.
  • Shaw PA; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Yip S; Department of Gynaecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
  • Lee CH; Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.
Genes Chromosomes Cancer ; 57(11): 598-603, 2018 11.
Article em En | MEDLINE | ID: mdl-30144186
Endometrial stromal sarcoma encompasses a heterogeneous group of uterine mesenchymal neoplasms, which are currently divided into low-grade and high-grade subtypes. Low-grade endometrial stromal sarcoma is morphologically bland; molecularly, these tumors frequently contain JAZF1-SUZ12, JAZF1-PHF1, and EPC1-PHF1 fusions. In contrast, high-grade endometrial stromal sarcoma is characterized by morphologically undifferentiated neoplasms with high-grade nuclear features; these tumors likewise appear to be genetically diverse with YWHAE-NUTM2 and ZC3H7B-BCOR representing the most frequent gene fusions. Herein, we describe two novel EPC1 fusion genes in endometrial stromal sarcoma: EPC1-SUZ12 and EPC1-BCOR. Both tumors were characterized be an aggressive clinical course.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Proteínas Cromossômicas não Histona / Proteínas de Fusão Oncogênica / Neoplasias do Endométrio / Sarcoma do Estroma Endometrial Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Proteínas Cromossômicas não Histona / Proteínas de Fusão Oncogênica / Neoplasias do Endométrio / Sarcoma do Estroma Endometrial Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article