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Sclerostin is expressed in the atherosclerotic plaques of patients who undergoing carotid endarterectomy.
Leto, Gaetano; D'Onofrio, Luca; Lucantoni, Federica; Zampetti, Simona; Campagna, Giuseppe; Foffi, Chiara; Moretti, Chiara; Carlone, Angela; Palermo, Andrea; Leopizzi, Martina; Porta, Natale; Massucci, Marco; Lenzi, Andrea; Bertoletti, Giovanni Battista; Rocca, Carlo Della; Buzzetti, Raffaella.
Afiliação
  • Leto G; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • D'Onofrio L; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • Lucantoni F; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • Zampetti S; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • Campagna G; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • Foffi C; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • Moretti C; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • Carlone A; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • Palermo A; Unit of Endocrinology and Diabetes Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy.
  • Leopizzi M; Department of medical-Surgical Sciences and Biotechnology, Polo Pontino Sapienza University of Rome, Rome, Italy.
  • Porta N; Department of medical-Surgical Sciences and Biotechnology, Polo Pontino Sapienza University of Rome, Rome, Italy.
  • Massucci M; Department of Vascular Surgery, Santa Maria Goretti Hospital, Latina, Italy.
  • Lenzi A; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • Bertoletti GB; Department of Vascular Surgery, Santa Maria Goretti Hospital, Latina, Italy.
  • Rocca CD; Department of medical-Surgical Sciences and Biotechnology, Polo Pontino Sapienza University of Rome, Rome, Italy.
  • Buzzetti R; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Diabetes Metab Res Rev ; 35(1): e3069, 2019 01.
Article em En | MEDLINE | ID: mdl-30144272
BACKGROUND: Sclerostin (SC) is a monomeric glycoprotein expressed by osteocytes that affects bone formation. Recent studies have suggested a potential role for this protein in the pathophysiology of vascular diseases. The aim of the present study was to investigate SC expression in atherosclerotic plaques of patients affected by severe atherosclerotic disease who underwent carotid endarterectomy. We also evaluated possible differences in SC expression between patients with and without type 2 diabetes (T2D). METHODS: This was a cross-sectional study involving 46 patients aged 55 to 80 years (mean, 71.1 ± 6.7 years, 36 men, 15 patients with T2D) who underwent carotid endarterectomy. Immunohistochemical levels of SC were evaluated in the atherosclerotic plaques by double-staining immunochemistry, and serum SC levels were evaluated by enzyme-linked immunosorbent assay. RESULTS: Sclerostin was present in the atherosclerotic plaques of all subjects investigated and increased significantly in the media compared with the intima (P < 0.0001) as well as in vascular smooth muscle cells (VSMCs) compared with the infiltrating macrophages (P < 0.0001). However, no significant difference in SC expression was observed between patients with and without T2D. No correlation was found between serum and immunohistochemical levels of SC; significantly increased SC serum levels were detected in males compared with females (P = 0.049). CONCLUSIONS: We have demonstrated, for the first time, the expression of SC in VSMCs of atherosclerotic plaques, suggesting a potential role for this protein in the development of atherosclerosis. Further studies are needed to understand if the role played by SC is detrimental or protective in the atherosclerotic disease process.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endarterectomia das Carótidas / Proteínas Morfogenéticas Ósseas / Diabetes Mellitus Tipo 2 / Placa Aterosclerótica Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endarterectomia das Carótidas / Proteínas Morfogenéticas Ósseas / Diabetes Mellitus Tipo 2 / Placa Aterosclerótica Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article