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Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma.
Sonntag, Roland; Giebeler, Nives; Nevzorova, Yulia A; Bangen, Jörg-Martin; Fahrenkamp, Dirk; Lambertz, Daniela; Haas, Ute; Hu, Wei; Gassler, Nikolaus; Cubero, Francisco Javier; Müller-Newen, Gerhard; Abdallah, Ali T; Weiskirchen, Ralf; Ticconi, Fabio; Costa, Ivan G; Barbacid, Mariano; Trautwein, Christian; Liedtke, Christian.
Afiliação
  • Sonntag R; Department of Internal Medicine III, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH), 52074 Aachen, Germany.
  • Giebeler N; Department of Internal Medicine III, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH), 52074 Aachen, Germany.
  • Nevzorova YA; Department of Internal Medicine III, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH), 52074 Aachen, Germany.
  • Bangen JM; Department of Internal Medicine III, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH), 52074 Aachen, Germany.
  • Fahrenkamp D; Institute of Biochemistry and Molecular Biology, University Hospital RWTH, 52074 Aachen, Germany.
  • Lambertz D; Department of Internal Medicine III, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH), 52074 Aachen, Germany.
  • Haas U; Department of Internal Medicine III, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH), 52074 Aachen, Germany.
  • Hu W; Department of Internal Medicine III, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH), 52074 Aachen, Germany.
  • Gassler N; Institute of Pathology, University Hospital RWTH, 52074 Aachen, Germany.
  • Cubero FJ; Department of Internal Medicine III, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH), 52074 Aachen, Germany.
  • Müller-Newen G; Institute of Biochemistry and Molecular Biology, University Hospital RWTH, 52074 Aachen, Germany.
  • Abdallah AT; Interdisciplinary Center for Clinical Research, University Hospital RWTH, 52074 Aachen, Germany.
  • Weiskirchen R; Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, University Hospital RWTH, 52074 Aachen, Germany.
  • Ticconi F; Institute for Computational Genomics, RWTH Aachen University, 52074 Aachen, Germany.
  • Costa IG; Institute for Computational Genomics, RWTH Aachen University, 52074 Aachen, Germany.
  • Barbacid M; Molecular Oncology, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain mbarbacid@cnio.es cliedtke@ukaachen.de.
  • Trautwein C; Department of Internal Medicine III, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH), 52074 Aachen, Germany.
  • Liedtke C; Department of Internal Medicine III, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH), 52074 Aachen, Germany; mbarbacid@cnio.es cliedtke@ukaachen.de.
Proc Natl Acad Sci U S A ; 115(37): 9282-9287, 2018 09 11.
Article em En | MEDLINE | ID: mdl-30150405
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Transformação Celular Neoplásica / Proteínas Oncogênicas / Carcinoma Hepatocelular / Ciclina E / Reparo do DNA / Quinase 2 Dependente de Ciclina / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Transformação Celular Neoplásica / Proteínas Oncogênicas / Carcinoma Hepatocelular / Ciclina E / Reparo do DNA / Quinase 2 Dependente de Ciclina / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article