Self-reported physician-diagnosed chronic obstructive pulmonary disease and spirometry patterns in Vietnam Era US Army Chemical Corps veterans: A retrospective cohort study.
Am J Ind Med
; 61(10): 802-814, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30159906
ABSTRACT
BACKGROUND:
Research on chronic obstructive pulmonary disease (COPD) and herbicide exposure in Vietnam War veterans is limited.METHODS:
Survey data were collected from 3193 US Army Chemical Corps veterans on herbicide exposure and self-reported physician-diagnosed COPD. Three spirometric patterns were used to define airflow obstruction (AFO) (i) FEV1 /FVC < 70% ("fixed ratio"); (ii) FEV1 /FVC < lower limit of normal ("LLN"); and (iii) (FEV1 /FVC < LLN and FVC ≥ LLN and FEV1RESULTS:
COPD prevalence varied (self-reports 20.1%; spirometry 29.8%, 12.9%, 8.4% by fixed ratio, LLN, and specific obstruction definitions, respectively). Spirometric parameters did not differ by exposure. Self-reported COPD and herbicide exposure were significantly associated (adjusted odds ratio [aOR] = 1.82, 95% confidence intervaI 1.48,2.24). No association was found between spirometric-AFO and herbicide exposure.CONCLUSIONS:
A significant association was found between herbicide exposure and self-reported physician-diagnosed COPD but not when COPD diagnosis was based on spirometry.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Veteranos
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Exposição Ocupacional
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Doença Pulmonar Obstrutiva Crônica
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Guerra do Vietnã
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Herbicidas
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Aged
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Humans
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Male
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Middle aged
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article