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IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo.
Guntuku, Lalita; Gangasani, Jagadeesh Kumar; Thummuri, Dinesh; Borkar, Roshan M; Manavathi, Bramanandam; Ragampeta, Srinivas; Vaidya, Jayathirtha Rao; Sistla, Ramakrishna; Vegi, Naidu G M.
Afiliação
  • Guntuku L; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hyderabad, TS, India.
  • Gangasani JK; Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, TS, India.
  • Thummuri D; Academy of Scientific and Innovative Research (AcSIR), Training and Development Complex, CSIR Campus, CSIR Road, Chennai, TN, India.
  • Borkar RM; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hyderabad, TS, India.
  • Manavathi B; National Centre for Mass Spectrometry, CSIR-Indian Institute of Chemical Technology, Hyderabad, TS, India.
  • Ragampeta S; Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, TS, India.
  • Vaidya JR; National Centre for Mass Spectrometry, CSIR-Indian Institute of Chemical Technology, Hyderabad, TS, India.
  • Sistla R; Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, TS, India.
  • Vegi NGM; Academy of Scientific and Innovative Research (AcSIR), Training and Development Complex, CSIR Campus, CSIR Road, Chennai, TN, India.
Oncogene ; 38(4): 581-595, 2019 01.
Article em En | MEDLINE | ID: mdl-30166591
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Neoplasias de Mama Triplo Negativas / Antineoplásicos Tipo de estudo: Clinical_trials Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Neoplasias de Mama Triplo Negativas / Antineoplásicos Tipo de estudo: Clinical_trials Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article