Human interferon-Ïµ and interferon-&#954; exhibit low potency and low affinity for cell-surface IFNAR and the poxvirus antagonist B18R.

Harris, Bethany D; Schreiter, Jessica; Chevrier, Marc; Jordan, Jarrat L; Walter, Mark R

Human interferon-Ïµ and interferon-κ exhibit low potency and low affinity for cell-surface IFNAR and the poxvirus antagonist B18R.

Harris, Bethany D; Schreiter, Jessica; Chevrier, Marc; Jordan, Jarrat L; Walter, Mark R.

Afiliação

Harris BD; From the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35243 and.
Schreiter J; Janssen Research & Development, LLC, Raritan, New Jersey 08869.
Chevrier M; Janssen Research & Development, LLC, Raritan, New Jersey 08869.
Jordan JL; Janssen Research & Development, LLC, Raritan, New Jersey 08869.
Walter MR; From the Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35243 and walter@uab.edu.

J Biol Chem ; 293(41): 16057-16068, 2018 10 12.

Article em En | MEDLINE | ID: mdl-30171073

Assuntos

Interferon Tipo I/metabolismo; Interferons/metabolismo; Receptor de Interferon alfa e beta/metabolismo; Proteínas Virais/metabolismo; Linhagem Celular; Expressão Gênica; Humanos; Interferon Tipo I/genética; Interferons/genética; Modelos Moleculares; Mutação; Ligação Proteica; Vaccinia virus/química

Palavras-chave

B18R; IFNAR; IFNκ; IFNÏµ; interferon; protein complex; protein-protein interaction; receptor structure-function; recombinant protein expression; structure-function; viral protein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Virais / Interferon Tipo I / Interferons / Receptor de Interferon alfa e beta Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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