Design and in vitro release study of siRNA loaded Layer by Layer nanoparticles with sustained gene silencing effect.

Tan, Yang Fei; Lee, Ying Shi; Seet, Li-Fong; Ng, Kee Woei; Wong, Tina T; Venkatraman, Subbu

Tan, Yang Fei; Lee, Ying Shi; Seet, Li-Fong; Ng, Kee Woei; Wong, Tina T; Venkatraman, Subbu.

Afiliação

Tan YF; a School of Materials Science and Engineering , Nanyang Technological University , Singapore.
Lee YS; b Ocular Therapeutics and Drug Delivery , Singapore Eye Research Institute , Singapore.
Seet LF; b Ocular Therapeutics and Drug Delivery , Singapore Eye Research Institute , Singapore.
Ng KW; c Department of Ophthalmology, Yong Loo Lin School of Medicine , National University of Singapore , Singapore.
Wong TT; d Duke-NUS Medical School , Singapore.
Venkatraman S; a School of Materials Science and Engineering , Nanyang Technological University , Singapore.

Expert Opin Drug Deliv ; 15(10): 937-949, 2018 10.

Article em En | MEDLINE | ID: mdl-30173580

Assuntos

Inativação Gênica; Nanopartículas; Osteonectina/genética; RNA Interferente Pequeno/administração & dosagem; Animais; Camundongos; Camundongos Endogâmicos C57BL; RNA Interferente Pequeno/genética

Palavras-chave

Layer-by-layer nanoparticles; drug release; fibrosis; mechanism; siRNA delivery

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteonectina / Inativação Gênica / RNA Interferente Pequeno / Nanopartículas Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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