Effect of Successful Treatment of Hepatitis C Virus Infection Recurrence With Direct-Acting Antiviral Agents on Physical Performance in Liver Transplant Recipients.
Transplant Proc
; 50(7): 2027-2030, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-30177103
ABSTRACT
BACKGROUND:
Hepatitis C virus (HCV) infection deregulates function of many organs and systems, affecting patient's daily functioning. The results of treatment of HCV infection recurrence after liver transplantation have improved significantly as a result of the introduction of direct-acting antiviral agents (DAA). This study was aimed at prospective assessment of the effect of HCV elimination with DAA on physical performance of liver transplant recipients.METHODS:
Eight women and 21 men, median age 61.3 (range, 20.1-71.5) years, participated in the study. Assessment of serum total bilirubin, alanine and aspartate aminotransferase, muscle strength, body composition, and 6-minute walk test (6MWT) were performed before treatment and 12 weeks after the end of the treatment period.RESULTS:
In the 6MWT test we observed significant subjective (dyspnea 58.3% pretreatment vs 27.6% posttreatment, P = .018; fatigue 96.6% pretreatment vs 51.7% posttreatment, P = .0001) and objective improvement (distance 415.4 meters pretreatment vs 505.2 meters posttreatment, P < .0000001). We did not observe an increase in muscle mass nor improvement in blood biochemical parameters.CONCLUSION:
A significant objective and subjective improvement in physical performance was seen in liver transplant recipients after successful treatment of HCV infection with DAA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Transplante de Fígado
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Hepatite C
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article