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A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties.
Pavlovic, Zvezdan; Adams, Jarrett J; Blazer, Levi L; Gakhal, Amandeep K; Jarvik, Nick; Steinhart, Zachary; Robitaille, Mélanie; Mascall, Keith; Pan, James; Angers, Stephane; Moffat, Jason; Sidhu, Sachdev S.
Afiliação
  • Pavlovic Z; a Terrence Donnelly Centre for Cellular and Biomolecular Research , University of Toronto , Toronto , Canada.
  • Adams JJ; a Terrence Donnelly Centre for Cellular and Biomolecular Research , University of Toronto , Toronto , Canada.
  • Blazer LL; a Terrence Donnelly Centre for Cellular and Biomolecular Research , University of Toronto , Toronto , Canada.
  • Gakhal AK; a Terrence Donnelly Centre for Cellular and Biomolecular Research , University of Toronto , Toronto , Canada.
  • Jarvik N; a Terrence Donnelly Centre for Cellular and Biomolecular Research , University of Toronto , Toronto , Canada.
  • Steinhart Z; b Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy , University of Toronto , Toronto , Canada.
  • Robitaille M; b Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy , University of Toronto , Toronto , Canada.
  • Mascall K; b Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy , University of Toronto , Toronto , Canada.
  • Pan J; a Terrence Donnelly Centre for Cellular and Biomolecular Research , University of Toronto , Toronto , Canada.
  • Angers S; b Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy , University of Toronto , Toronto , Canada.
  • Moffat J; c Department of Biochemistry , University of Toronto , Toronto , Canada.
  • Sidhu SS; a Terrence Donnelly Centre for Cellular and Biomolecular Research , University of Toronto , Toronto , Canada.
MAbs ; 10(8): 1157-1167, 2018.
Article em En | MEDLINE | ID: mdl-30183492
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Receptores Frizzled / Anticorpos Monoclonais / Especificidade de Anticorpos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Receptores Frizzled / Anticorpos Monoclonais / Especificidade de Anticorpos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article