Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.

Beaupere, Carine; Dinatto, Leticia; Wasko, Brian M; Chen, Rosalyn B; VanValkenburg, Lauren; Kiflezghi, Michael G; Lee, Mitchell B; Promislow, Daniel E L; Dang, Weiwei; Kaeberlein, Matt; Labunskyy, Vyacheslav M

Beaupere, Carine; Dinatto, Leticia; Wasko, Brian M; Chen, Rosalyn B; VanValkenburg, Lauren; Kiflezghi, Michael G; Lee, Mitchell B; Promislow, Daniel E L; Dang, Weiwei; Kaeberlein, Matt; Labunskyy, Vyacheslav M.

Afiliação

Beaupere C; Department of Dermatology, Boston University School of Medicine, Boston, MA 02118.
Dinatto L; Department of Dermatology, Boston University School of Medicine, Boston, MA 02118.
Wasko BM; Department of Pathology, University of Washington, Seattle, WA 98195.
Chen RB; Department of Dermatology, Boston University School of Medicine, Boston, MA 02118.
VanValkenburg L; Department of Dermatology, Boston University School of Medicine, Boston, MA 02118.
Kiflezghi MG; Department of Pathology, University of Washington, Seattle, WA 98195.
Lee MB; Department of Pathology, University of Washington, Seattle, WA 98195.
Promislow DEL; Department of Pathology, University of Washington, Seattle, WA 98195.
Dang W; Department of Biology, University of Washington, Seattle, WA 98195.
Kaeberlein M; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Labunskyy VM; Department of Pathology, University of Washington, Seattle, WA 98195.

Proc Natl Acad Sci U S A ; 115(38): 9586-9591, 2018 09 18.

Article em En | MEDLINE | ID: mdl-30185560

Assuntos

Adaptação Fisiológica/genética; Aneuploidia; Estresse do Retículo Endoplasmático/genética; Regulação Fúngica da Expressão Gênica/fisiologia; Saccharomyces cerevisiae/fisiologia; Cromossomos Fúngicos/genética; Farmacorresistência Fúngica/genética; Fosfotransferases (Aceptor do Grupo Fosfato)/genética; Fosfotransferases (Aceptor do Grupo Fosfato)/metabolismo; Complexo de Endopeptidases do Proteassoma/genética; Complexo de Endopeptidases do Proteassoma/metabolismo; Dobramento de Proteína; Tunicamicina/farmacologia; Resposta a Proteínas não Dobradas/fisiologia

Palavras-chave

ER stress resistance; Saccharomyces cerevisiae; aneuploidy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Adaptação Fisiológica / Regulação Fúngica da Expressão Gênica / Estresse do Retículo Endoplasmático / Aneuploidia Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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