Coupling of bone resorption and formation by RANKL reverse signalling.
Nature
; 561(7722): 195-200, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30185903
ABSTRACT
Receptor activator of nuclear factor-kappa B (RANK) ligand (RANKL) binds RANK on the surface of osteoclast precursors to trigger osteoclastogenesis. Recent studies have indicated that osteocytic RANKL has an important role in osteoclastogenesis during bone remodelling; however, the role of osteoblastic RANKL remains unclear. Here we show that vesicular RANK, which is secreted from the maturing osteoclasts, binds osteoblastic RANKL and promotes bone formation by triggering RANKL reverse signalling, which activates Runt-related transcription factor 2 (Runx2). The proline-rich motif in the RANKL cytoplasmic tail is required for reverse signalling, and a RANKL(Pro29Ala) point mutation reduces activation of the reverse signalling pathway. The coupling of bone resorption and formation is disrupted in RANKL(Pro29Ala) mutant mice, indicating that osteoblastic RANKL functions as a coupling signal acceptor that recognizes vesicular RANK. RANKL reverse signalling is therefore a potential pharmacological target for avoiding the reduced bone formation associated with inhibition of osteoclastogenesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteogênese
/
Reabsorção Óssea
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Transdução de Sinais
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Ligante RANK
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article