The EGF-LIKE domain of thrombospondin-4 is a key determinant in the development of pain states due to increased excitatory synaptogenesis.

Park, John Francisco; Yu, Yanhui Peter; Gong, Nian; Trinh, Van Nancy; Luo, Z David

Park, John Francisco; Yu, Yanhui Peter; Gong, Nian; Trinh, Van Nancy; Luo, Z David.

Afiliação

Park JF; From the Departments of Pharmacology and.
Yu YP; From the Departments of Pharmacology and.
Gong N; Anesthesiology and Perioperative Care, University of California, Irvine, California 92697.
Trinh VN; Anesthesiology and Perioperative Care, University of California, Irvine, California 92697.
Luo ZD; From the Departments of Pharmacology and zluo@uci.edu.

J Biol Chem ; 293(42): 16453-16463, 2018 10 19.

Article em En | MEDLINE | ID: mdl-30194282

Assuntos

Fator de Crescimento Epidérmico/química; Neuralgia/etiologia; Trombospondinas/química; Animais; Canais de Cálcio/metabolismo; Medição da Dor; Domínios Proteicos; Ratos; Células Receptoras Sensoriais/metabolismo; Medula Espinal/metabolismo; Sinapses

Palavras-chave

TSP4; allodynia; calcium channel; extracellular matrix protein; neuropathic pain; pain; pro-nociceptive domain; synaptic plasticity; synaptogenesis; thrombospondin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trombospondinas / Fator de Crescimento Epidérmico / Neuralgia Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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