Disulfide-based PEGylated prodrugs: Reconversion kinetics, self-assembly and antitumor efficacy.
Colloids Surf B Biointerfaces
; 172: 414-422, 2018 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-30195159
ABSTRACT
The prodrug strategy serves well in drug formulation and delivery. Two disulfide-based PEGylated prodrugs were developed and the drug reconversion upon different conditions were studied in detail. The reconversion-induced oversaturation phenomenon was firstly reported here. We found the prodrug can co-assemble with parent drug via π-π stacking into well-defined nanoparticles. The PEG layer of the self-assembled nanoparticles improved the stability of the PEGylated prodrug by reducing the contact with biological enzymes. The nanoparticles also show favorable antitumor efficacy, both in vitro and in vivo.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
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Pró-Fármacos
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Dissulfetos
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Antineoplásicos
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article