Heterogeneous distribution of trastuzumab in HER2-positive xenografts and metastases: role of the tumor microenvironment.

Baker, Jennifer Hazel Elizabeth; Kyle, Alastair Hugh; Reinsberg, Stefan Alexander; Moosvi, Firas; Patrick, Haley Margaret; Cran, Jordan; Saatchi, Katayoun; Häfeli, Urs; Minchinton, Andrew Ivor

Baker, Jennifer Hazel Elizabeth; Kyle, Alastair Hugh; Reinsberg, Stefan Alexander; Moosvi, Firas; Patrick, Haley Margaret; Cran, Jordan; Saatchi, Katayoun; Häfeli, Urs; Minchinton, Andrew Ivor.

Afiliação

Baker JHE; Integrative Oncology - Radiation Biology Unit, BC Cancer Research Centre, 675 West 10th Ave, Vancouver, BC, V5Z 1L3, Canada. jbaker@bccrc.ca.
Kyle AH; Integrative Oncology - Radiation Biology Unit, BC Cancer Research Centre, 675 West 10th Ave, Vancouver, BC, V5Z 1L3, Canada.
Reinsberg SA; Department of Physics & Astronomy, University of British Columbia, Vancouver, Canada.
Moosvi F; Department of Physics & Astronomy, University of British Columbia, Vancouver, Canada.
Patrick HM; Integrative Oncology - Radiation Biology Unit, BC Cancer Research Centre, 675 West 10th Ave, Vancouver, BC, V5Z 1L3, Canada.
Cran J; Integrative Oncology - Radiation Biology Unit, BC Cancer Research Centre, 675 West 10th Ave, Vancouver, BC, V5Z 1L3, Canada.
Saatchi K; Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Häfeli U; Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Minchinton AI; Integrative Oncology - Radiation Biology Unit, BC Cancer Research Centre, 675 West 10th Ave, Vancouver, BC, V5Z 1L3, Canada.

Clin Exp Metastasis ; 35(7): 691-705, 2018 10.

Article em En | MEDLINE | ID: mdl-30196384

Assuntos

Neoplasias da Mama/metabolismo; Receptor ErbB-2/metabolismo; Trastuzumab/farmacocinética; Animais; Antineoplásicos Imunológicos/administração & dosagem; Antineoplásicos Imunológicos/farmacocinética; Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem; Protocolos de Quimioterapia Combinada Antineoplásica/farmacocinética; Bevacizumab/administração & dosagem; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/enzimologia; Neoplasias Encefálicas/secundário; Neoplasias da Mama/irrigação sanguínea; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Feminino; Humanos; Camundongos; Camundongos Endogâmicos NOD; Camundongos SCID; Receptor ErbB-2/biossíntese; Trastuzumab/administração & dosagem; Microambiente Tumoral; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Bevacizumab; Brain metastases; DCE-MRI; Drug distribution; HER2-positive metastases; HER2/neu; Herceptin; Monoclonal antibody therapeutic; Tumor microenvironment; Tumor vessel permeability

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Receptor ErbB-2 / Trastuzumab Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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