Widespread Expression of Hedgehog Pathway Components in a Large Panel of Human Tumor Cells and Inhibition of Tumor Growth by GANT61: Implications for Cancer Therapy.

Réda, Jiri; Vachtenheim, Jiri; Vlcková, Katerina; Horák, Pavel; Vachtenheim, Jiri; Ondrusová, Lubica

Réda, Jiri; Vachtenheim, Jiri; Vlcková, Katerina; Horák, Pavel; Vachtenheim, Jiri; Ondrusová, Lubica.

Afiliação

Réda J; Department of Transcription and Cell Signaling, Institute of Medical Biochemistry and Laboratory Diagnostics, Charles University Prague, 12108 Prague, Czech Republic. RedaJ@seznam.cz.
Vachtenheim J; Department of Transcription and Cell Signaling, Institute of Medical Biochemistry and Laboratory Diagnostics, Charles University Prague, 12108 Prague, Czech Republic. jiri.vachtenheim@lf1.cuni.cz.
Vlcková K; Department of Transcription and Cell Signaling, Institute of Medical Biochemistry and Laboratory Diagnostics, Charles University Prague, 12108 Prague, Czech Republic. vlckova.katka@centrum.cz.
Horák P; Department of Transcription and Cell Signaling, Institute of Medical Biochemistry and Laboratory Diagnostics, Charles University Prague, 12108 Prague, Czech Republic. ppavel.hhorak@gmail.com.
Vachtenheim J; Third Department of Surgery, First Faculty of Medicine, Charles University Prague and University Hospital Motol, 15006 Prague, Czech Republic. jcdv@seznam.cz.
Ondrusová L; Department of Transcription and Cell Signaling, Institute of Medical Biochemistry and Laboratory Diagnostics, Charles University Prague, 12108 Prague, Czech Republic. lubica.ondrusova@gmail.com.

Int J Mol Sci ; 19(9)2018 Sep 10.

Article em En | MEDLINE | ID: mdl-30201866

Assuntos

Proteínas Hedgehog/metabolismo; Neoplasias/metabolismo; Proteínas Nucleares/metabolismo; Piridinas/farmacologia; Pirimidinas/farmacologia; Proteína GLI1 em Dedos de Zinco/metabolismo; Proteína Gli2 com Dedos de Zinco/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Progressão da Doença; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Células HeLa; Humanos; Células Jurkat; Neoplasias/tratamento farmacológico; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

GANT61; GLI; Hedgehog; apoptosis; tumor cell lines

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Pirimidinas / Proteínas Nucleares / Proteínas Hedgehog / Proteína GLI1 em Dedos de Zinco / Proteína Gli2 com Dedos de Zinco / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google