Iron overload by transferrin receptor protein 1 regulation plays an important role in palmitate-induced insulin resistance in human skeletal muscle cells.

Cui, Rihua; Choi, Sung-E; Kim, Tae Ho; Lee, Hwa Joung; Lee, Soo Jin; Kang, Yup; Jeon, Ja Young; Kim, Hae Jin; Lee, Kwan-Woo

Cui, Rihua; Choi, Sung-E; Kim, Tae Ho; Lee, Hwa Joung; Lee, Soo Jin; Kang, Yup; Jeon, Ja Young; Kim, Hae Jin; Lee, Kwan-Woo.

Afiliação

Cui R; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea.
Choi SE; Department of Physiology, Ajou University School of Medicine, Suwon, South Korea.
Kim TH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul Medical Center, Seoul, South Korea.
Lee HJ; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea.
Lee SJ; Department of Physiology, Ajou University School of Medicine, Suwon, South Korea.
Kang Y; Department of Physiology, Ajou University School of Medicine, Suwon, South Korea.
Jeon JY; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea.
Kim HJ; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea.
Lee KW; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea.

FASEB J ; 33(2): 1771-1786, 2019 02.

Article em En | MEDLINE | ID: mdl-30207798

Assuntos

Antígenos CD/metabolismo; Resistência à Insulina; Sobrecarga de Ferro/metabolismo; Músculo Esquelético/efeitos dos fármacos; Ácido Palmítico/farmacologia; Receptores da Transferrina/metabolismo; Adulto; Animais; Antígenos CD/genética; Estudos de Casos e Controles; Células Cultivadas; Desferroxamina/farmacologia; Diabetes Mellitus Tipo 2/metabolismo; Ativação Enzimática; Técnicas de Silenciamento de Genes; Humanos; Quelantes de Ferro/farmacologia; MAP Quinase Quinase 4/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Músculo Esquelético/citologia; Músculo Esquelético/metabolismo; Receptores da Transferrina/genética

Palavras-chave

calcium; free fatty acids; iron disturbances; iron-responsive element-binding proteins 2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores da Transferrina / Resistência à Insulina / Antígenos CD / Músculo Esquelético / Sobrecarga de Ferro / Ácido Palmítico Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Animals / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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