Direct C-4 alkylation of quinazoline N-oxides with ethers via an oxidative cross-coupling reaction under metal-free conditions.
Org Biomol Chem
; 16(45): 8724-8731, 2018 11 21.
Article
em En
| MEDLINE
| ID: mdl-30209478
ABSTRACT
A novel and efficient protocol for the direct C-4 alkylation of quinazoline-3-oxides via radical oxidative coupling between quinazoline 3-oxides and ethers in the presence of TBHP was developed. The reaction proceeded smoothly under metal-free conditions, which provided quinazoline-containing heterocyclic molecules in moderate to good yields.
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MEDLINE
Idioma:
En
Ano de publicação:
2018
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Article