Medermycin-Type Naphthoquinones from the Marine-Derived Streptomyces sp. XMA39.
J Nat Prod
; 81(9): 2120-2124, 2018 09 28.
Article
em En
| MEDLINE
| ID: mdl-30209946
ABSTRACT
Four new medermycin-type naphthoquinones, strepoxepinmycins A-D (1-4), and one known compound, medermycin (5), were identified from Streptomyces sp. XMA39. Their structures were elucidated by analysis of HRESIMS, 1D and 2D NMR spectroscopic data, and ECD calculations. Among these compounds, strepoxepinmycin A (1) represents a rare 5,10-oxepindione ring system typically formed by a Baeyer-Villiger oxidation, and strepoxepinmycin B (2) is an isolation artifact derived from 1. Bioactivity evaluations of these compounds showed that compounds 3 and 4 exhibited cytotoxicity against HCT-116 and PC-3 cancer cell lines and 4 exhibited moderate inhibition of ROCK 2 protein kinase. In addition, all of the new compounds showed antibacterial activity against Escherichia coli and methicillin-resistant Staphylococcus aureus and antifungal activity against Candida albicans.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Microbiologia da Água
/
Naftoquinonas
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article