Analysis of Risk Factors Increased Hemorrhagic Transformation after Acute Ischemic Stroke.
J Stroke Cerebrovasc Dis
; 27(12): 3587-3590, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-30217636
ABSTRACT
BACKGROUND:
The purpose of this study was to analyze the risk factors of hemorrhagic transformation (HT) after intravenous thrombolysis using a recombinant tissue plasminogen activator (r-tPA) in acute ischemic stroke (AIS).METHODS:
We included 199 consecutive patients in the First Affiliated Hospital of Wenzhou Medical University from January 2016 to October 2017 with a diagnosis of AIS. The patients were divided into 2 groups HT and non-HT. The related risk factors were recruited before and after receiving r-tPA thrombolysis.RESULTS:
Using univariate analysis, we found that there was a significant difference between the HT and non-HT group (P < .05) in the level of age, atrial fibrillation, baseline National Institute of Health Stroke Scale (NIHSS) score and NIHSS score after 2 hours of thrombolytic therapy, hyperlipidemia. Multivariate logistic regression analysis indicated that NIHSS score after 2 hours of thrombolytic therapy (odds ratio [OR]â¯=â¯1.091, 95% confidence interval [CI] = 1.015-1.173 Pâ¯=â¯.018) and atrial fibrillation (ORâ¯=â¯2.188, 95%CI â¯=â¯1.024-4.672 Pâ¯=â¯.043) are the risk factors of HT.CONCLUSIONS:
NIHSS score after 2 hours of thrombolytic therapy and atrial fibrillation were risk factors for HT after thrombolysis. Age (ORâ¯=â¯1.022, 95%CI = .988-1.056 Pâ¯=â¯.205), Hyperlipidemia (ORâ¯=â¯.591, 95%CI = .29-1.206 Pâ¯=â¯.148), and Baseline NIHSS score (ORâ¯=â¯.998, 95%CI = .914-1.089 Pâ¯=â¯.043) were not significant independent predictors but showed an association with HT. These 5 factors should be carefully taken into account.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Hemorragia Cerebral
/
Isquemia Encefálica
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Acidente Vascular Cerebral
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article