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Drug Repurposing of Metabolic Agents in Malignant Glioma.
Seliger, Corinna; Hau, Peter.
Afiliação
  • Seliger C; Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, 93053 Regensburg, Germany. corinna.seliger@ukr.de.
  • Hau P; Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, 93053 Regensburg, Germany. peter.hau@ukr.de.
Int J Mol Sci ; 19(9)2018 Sep 14.
Article em En | MEDLINE | ID: mdl-30223473
Gliomas are highly invasive brain tumors with short patient survival. One major pathogenic factor is aberrant tumor metabolism, which may be targeted with different specific and unspecific agents. Drug repurposing is of increasing interest in glioma research. Drugs interfering with the patient's metabolism may also influence glioma metabolism. In this review, we outline definitions and methods for drug repurposing. Furthermore, we give insights into important candidates for a metabolic drug repurposing, namely metformin, statins, non-steroidal anti-inflammatory drugs, disulfiram and lonidamine. Advantages and pitfalls of drug repurposing will finally be discussed.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Metabolismo Energético / Reposicionamento de Medicamentos / Glioma / Antimetabólitos Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Metabolismo Energético / Reposicionamento de Medicamentos / Glioma / Antimetabólitos Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article