Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer's disease model.

Furotani, Koto; Kamimura, Keisuke; Yajima, Takaaki; Nakayama, Minoru; Enomoto, Rena; Tamura, Takuya; Okazawa, Hitoshi; Sone, Masaki

Furotani, Koto; Kamimura, Keisuke; Yajima, Takaaki; Nakayama, Minoru; Enomoto, Rena; Tamura, Takuya; Okazawa, Hitoshi; Sone, Masaki.

Afiliação

Furotani K; Faculty of Science, Toho University, Funabashi, Japan.
Kamimura K; Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Yajima T; Faculty of Science, Toho University, Funabashi, Japan.
Nakayama M; Faculty of Science, Toho University, Funabashi, Japan.
Enomoto R; Faculty of Science, Toho University, Funabashi, Japan.
Tamura T; Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Okazawa H; Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Sone M; Faculty of Science, Toho University, Funabashi, Japan.

PLoS One ; 13(9): e0204048, 2018.

Article em En | MEDLINE | ID: mdl-30226901

Assuntos

Doença de Alzheimer/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Drosophila melanogaster/metabolismo; Sinapses/metabolismo; Doença de Alzheimer/prevenção & controle; Animais; Modelos Animais de Doenças; Proteínas de Drosophila/genética; Drosophila melanogaster/genética; Feminino; Técnicas de Silenciamento de Genes; Masculino; Proteínas do Tecido Nervoso/metabolismo; Proteínas Quinases/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinapses / Precursor de Proteína beta-Amiloide / Drosophila melanogaster / Doença de Alzheimer Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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