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Path mediation analysis reveals GBA impacts Lewy body disease status by increasing α-synuclein levels.
Gündner, Anna Lisa; Duran-Pacheco, Gonzalo; Zimmermann, Silke; Ruf, Iris; Moors, Tim; Baumann, Karlheinz; Jagasia, Ravi; van de Berg, Wilma D J; Kremer, Thomas.
Afiliação
  • Gündner AL; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel 4070, Switzerland. Electronic address: Anna_Lisa.Guendner@roche.com.
  • Duran-Pacheco G; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel 4070, Switzerland.
  • Zimmermann S; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel 4070, Switzerland.
  • Ruf I; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel 4070, Switzerland.
  • Moors T; Department of Anatomy & Neurosciences, Section Clinical Neuroanatomy, VU University Medical center (VUmc), Boelelaan 1108, 1081, Amsterdam.
  • Baumann K; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel 4070, Switzerland.
  • Jagasia R; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel 4070, Switzerland.
  • van de Berg WDJ; Department of Anatomy & Neurosciences, Section Clinical Neuroanatomy, VU University Medical center (VUmc), Boelelaan 1108, 1081, Amsterdam.
  • Kremer T; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Basel 4070, Switzerland. Electronic address: Thomas.Kremer@roche.com.
Neurobiol Dis ; 121: 205-213, 2019 01.
Article em En | MEDLINE | ID: mdl-30236861
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Encéfalo / Doença por Corpos de Lewy / Alfa-Sinucleína / Glucosilceramidase Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Encéfalo / Doença por Corpos de Lewy / Alfa-Sinucleína / Glucosilceramidase Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article