Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment.

Valnohova, Jana; Kowalski-Jahn, Maria; Sunahara, Roger K; Schulte, Gunnar

Valnohova, Jana; Kowalski-Jahn, Maria; Sunahara, Roger K; Schulte, Gunnar.

Afiliação

Valnohova J; From the Section for Receptor Biology and Signaling, Department of Physiology and Pharmacology, Karolinska Institutet, 171 65 Stockholm, Sweden.
Kowalski-Jahn M; From the Section for Receptor Biology and Signaling, Department of Physiology and Pharmacology, Karolinska Institutet, 171 65 Stockholm, Sweden.
Sunahara RK; Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, California 92093.
Schulte G; From the Section for Receptor Biology and Signaling, Department of Physiology and Pharmacology, Karolinska Institutet, 171 65 Stockholm, Sweden. Electronic address: gunnar.schulte@ki.se.

J Biol Chem ; 293(46): 17875-17887, 2018 11 16.

Article em En | MEDLINE | ID: mdl-30237173

Assuntos

Proteínas Desgrenhadas/metabolismo; Receptores Frizzled/metabolismo; Aciltransferases/antagonistas & inibidores; Benzenoacetamidas/farmacologia; Sítios de Ligação; Membrana Celular/metabolismo; Cisteína/química; Receptores Frizzled/genética; Células HEK293; Humanos; Proteínas de Membrana/antagonistas & inibidores; Mutagênese; Mutação; Domínios Proteicos; Piridinas/farmacologia; Proteínas Wnt/metabolismo; Via de Sinalização Wnt

Palavras-chave

DVL; FZD6; G protein signaling; G proteincoupled receptor (GPCR); Wnt signaling; linker domain; membrane protein; mutagenesis; protein structure; ß-catenin

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Frizzled / Proteínas Desgrenhadas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google