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Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo.
Hoff, Nicole A; Mukadi, Patrick; Doshi, Reena H; Bramble, Matthew S; Lu, Kai; Gadoth, Adva; Sinai, Cyrus; Spencer, D'Andre; Nicholson, Bradley P; Williams, Russell; Mossoko, Matthias; Ilunga-Kebela, Benoit; Wasiswa, Joseph; Okitolonda-Wemakoy, Emile; Alfonso, Vivian H; Steffen, Imke; Muyembe-Tamfum, Jean-Jacques; Simmons, Graham; Rimoin, Anne W.
Afiliação
  • Hoff NA; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles.
  • Mukadi P; Institut National de Recherche Biomédicale, Washington, District of Columbia.
  • Doshi RH; Faculté de Médecine, Université de Kinshasa, Democratic Republic of the Congo (DRC), Washington, District of Columbia.
  • Bramble MS; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles.
  • Lu K; Department of Genetic Medicine Research, Children's Research Institute, Children's National Medical Center, Washington, District of Columbia.
  • Gadoth A; Blood Systems Research Institute, San Francisco.
  • Sinai C; Department of Laboratory Medicine, University of California, San Francisco.
  • Spencer D; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles.
  • Nicholson BP; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles.
  • Williams R; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles.
  • Mossoko M; Molecular Epidemiology Research Laboratory, Veterans Affairs Medical Center, Durham, North Carolina.
  • Ilunga-Kebela B; University of California, Los Angeles-DRC Research Program.
  • Wasiswa J; Direction de lutte contre la Maladie, Ministère de la Santé Publique.
  • Okitolonda-Wemakoy E; Direction de lutte contre la Maladie, Ministère de la Santé Publique.
  • Alfonso VH; University of California, Los Angeles-DRC Research Program.
  • Steffen I; Direction de lutte contre la Maladie, Ministère de la Santé Publique.
  • Muyembe-Tamfum JJ; Ecole de Sante Publique, Université de Kinshasa, DRC.
  • Simmons G; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles.
  • Rimoin AW; Blood Systems Research Institute, San Francisco.
J Infect Dis ; 219(4): 517-525, 2019 01 29.
Article em En | MEDLINE | ID: mdl-30239838
ABSTRACT
Healthcare settings have played a major role in propagation of Ebola virus (EBOV) outbreaks. Healthcare workers (HCWs) have elevated risk of contact with EBOV-infected patients, particularly if safety precautions are not rigorously practiced. We conducted a serosurvey to determine seroprevalence against multiple EBOV antigens among HCWs of Boende Health Zone, Democratic Republic of the Congo, the site of a 2014 EBOV outbreak. Interviews and specimens were collected from 565 consenting HCWs. Overall, 234 (41.4%) of enrolled HCWs were reactive to at least 1 EBOV protein 159 (28.1%) were seroreactive for anti-glycoprotein immunoglobulin G (IgG), 89 (15.8%) were seroreactive for anti-nucleoprotein IgG, and 54 (9.5%) were VP40 positive. Additionally, sera from 16 (2.8%) HCWs demonstrated neutralization capacity. These data demonstrate that a significant proportion of HCWs have the ability to neutralize virus, despite never having developed Ebola virus disease symptoms, highlighting an important and poorly documented aspect of EBOV infection and progression.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estudos Soroepidemiológicos / Pessoal de Saúde / Ebolavirus / Anticorpos Antivirais Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País como assunto: Africa Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estudos Soroepidemiológicos / Pessoal de Saúde / Ebolavirus / Anticorpos Antivirais Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País como assunto: Africa Idioma: En Ano de publicação: 2019 Tipo de documento: Article