Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development.
Gastroenterology
; 156(2): 338-354, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30243619
ABSTRACT
Many cell culture and animal models have been used to study hepatitis B virus (HBV) replication and its effects in the liver; these have facilitated development of strategies to control and clear chronic HBV infection. We discuss the advantages and limitations of systems for studying HBV and developing antiviral agents, along with recent advances. New and improved model systems are needed. Cell culture systems should be convenient, support efficient HBV infection, and reproduce responses of hepatocytes in the human body. We also need animals that are fully permissive to HBV infection, convenient for study, and recapitulate human immune responses to HBV and effects in the liver. High-throughput screening technologies could facilitate drug development based on findings from cell and animal models.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vírus da Hepatite B
/
Modelos Imunológicos
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Técnicas de Cultura de Células
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Modelos Animais de Doenças
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Desenvolvimento de Medicamentos
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Hepatite B
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article