Visible light catalyzed reaction of α-bromochalcones with chalcones: direct access to the urundeuvine scaffold.
Org Biomol Chem
; 16(39): 7152-7156, 2018 10 10.
Article
em En
| MEDLINE
| ID: mdl-30246853
ABSTRACT
The α-keto vinyl radicals generated from α-bromochalcones under visible light photoredox catalyzed conditions were trapped by chalcones. The subsequent intramolecular cyclization of the resulting benzylic radicals led to the synthesis of dihydronaphthalenes, which were conveniently oxidized to the corresponding naphthalenes. The strategy was adopted successfully for synthesizing derivatives of urundeuvine chalcones, which are otherwise accessible only from natural sources.
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MEDLINE
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En
Ano de publicação:
2018
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Article