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Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2.
Wu, Lili; Chen, Yulian; Liu, Han; Zhan, Zhikun; Liang, Zhi; Zhang, Tao; Cai, Zheng; Ye, Ling; Liu, Menghua; Zhao, Jie; Liu, Shuwen; Tang, Lan.
Afiliação
  • Wu L; Biopharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Chen Y; Biopharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Liu H; Biopharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Zhan Z; Biopharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Liang Z; Biopharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Zhang T; Biopharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Cai Z; Biopharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Ye L; Biopharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Liu M; Biopharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Zhao J; Biopharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Liu S; Biopharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Tang L; Biopharmaceutics, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.. Electronic address: tl405@smu.edu.cn.
Toxicol Appl Pharmacol ; 359: 91-101, 2018 11 15.
Article em En | MEDLINE | ID: mdl-30248416
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fármacos Renais / Catárticos / Probenecid / Emodina / Glucuronosiltransferase / Transportadores de Cassetes de Ligação de ATP / Doença Hepática Induzida por Substâncias e Drogas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fármacos Renais / Catárticos / Probenecid / Emodina / Glucuronosiltransferase / Transportadores de Cassetes de Ligação de ATP / Doença Hepática Induzida por Substâncias e Drogas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article