Genetic Association between Serum 25-Hydroxyvitamin D Levels and Lung Function in Korean Men and Women: Data from KNHANES 2011â»2012.
Nutrients
; 10(10)2018 Sep 23.
Article
em En
| MEDLINE
| ID: mdl-30249031
ABSTRACT
The association between single-nucleotide polymorphisms (SNPs) in the vitamin D metabolic pathway and lung function is unknown. We examined the association between five SNPs on DHCR7, GC, CYP2R1, and CYP24A1 along with serum 25-hydroxyvitamin D (25(OH)D) levels and lung function in older Korean men (n = 758) and women (n = 837). Lung function was determined by forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) from the data in the Korea Nutrition and Health Examination Survey 2011â»2012. Genetic risk score (GRS) was calculated by the number of 25(OH)D-decreasing alleles of the five SNPs. Our results showed that increases in GRS were associated with reduced 25(OH)D levels (p < 0.05 for both sexes). In the entire population, FVC and FEV1 were associated with both GRS and 25(OH)D levels. In women, FVC and FEV1 were negatively associated with GRS (ß-coefficient (95% CI) -0.022 (-0.039, -0.005) and -0.020 (-0.035, -0.005), respectively; both p < 0.05), but not with 25(OH)D. However, in men, FVC and FEV1 were positively associated with 25(OH)D (ß-coefficient (95% CI) 0.008 (0.001, 0.016) and 0.008 (0.002, 0.015), respectively; both p < 0.05), but not with GRS. In conclusion, lung function was associated with genetic variation in Korean women and with 25(OH)D in Korean men.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
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Proteína de Ligação a Vitamina D
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Polimorfismo de Nucleotídeo Único
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Oxirredutases atuantes sobre Doadores de Grupo CH-CH
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Colestanotriol 26-Mono-Oxigenase
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Vitamina D3 24-Hidroxilase
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Família 2 do Citocromo P450
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Pulmão
Tipo de estudo:
Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article