Enterobacter cloacae Complex Sequence Type 171 Isolates Expressing KPC-4 Carbapenemase Recovered from Canine Patients in Ohio.

Daniels, Joshua B; Chen, Liang; Grooters, Susan V; Mollenkopf, Dixie F; Mathys, Dimitria A; Pancholi, Preeti; Kreiswirth, Barry N; Wittum, Thomas E

Daniels, Joshua B; Chen, Liang; Grooters, Susan V; Mollenkopf, Dixie F; Mathys, Dimitria A; Pancholi, Preeti; Kreiswirth, Barry N; Wittum, Thomas E.

Afiliação

Daniels JB; Department of Veterinary Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA josh.daniels@colostate.edu.
Chen L; Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Grooters SV; Department of Veterinary Preventive Medicine, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
Mollenkopf DF; Department of Veterinary Preventive Medicine, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
Mathys DA; Department of Veterinary Preventive Medicine, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
Pancholi P; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Kreiswirth BN; Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Wittum TE; Department of Veterinary Preventive Medicine, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.

Antimicrob Agents Chemother ; 62(12)2018 12.

Article em En | MEDLINE | ID: mdl-30249699

ABSTRACT

ABSTRACT

Companion animals are likely relevant in the transmission of antimicrobial-resistant bacteria. Enterobacter xiangfangensis sequence type 171 (ST171), a clone that has been implicated in clusters of infections in humans, was isolated from two dogs with clinical disease in Ohio. The canine isolates contained IncHI2 plasmids encoding blaKPC-4 Whole-genome sequencing was used to put the canine isolates in phylogenetic context with available human ST171 sequences, as well as to characterize their blaKPC-4 plasmids.

Assuntos

Proteínas de Bactérias/genética; Enterobacter cloacae/genética; Infecções por Enterobacteriaceae/veterinária; Plasmídeos/química; Resistência beta-Lactâmica/genética; beta-Lactamases/genética; Animais; Antibacterianos/farmacologia; Proteínas de Bactérias/metabolismo; Carbapenêmicos/farmacologia; Cães; Enterobacter cloacae/classificação; Enterobacter cloacae/efeitos dos fármacos; Enterobacter cloacae/isolamento & purificação; Infecções por Enterobacteriaceae/diagnóstico; Infecções por Enterobacteriaceae/microbiologia; Infecções por Enterobacteriaceae/patologia; Feminino; Expressão Gênica; Masculino; Testes de Sensibilidade Microbiana; Tipagem de Sequências Multilocus; Ohio; Filogenia; Plasmídeos/metabolismo; Sequenciamento Completo do Genoma; beta-Lactamases/metabolismo

Palavras-chave

antibiotic resistance; carbapenemase; plasmid-mediated resistance; veterinary microbiology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmídeos / Proteínas de Bactérias / Beta-Lactamases / Enterobacter cloacae / Resistência beta-Lactâmica / Infecções por Enterobacteriaceae Tipo de estudo: Diagnostic_studies Limite: Animals País como assunto: America do norte Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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