The mouse immunoglobulin heavy-chain gene enhancer contains sequences that inhibit transcription in vitro in HeLa cell extracts.
Mol Cell Biol
; 6(11): 4117-21, 1986 Nov.
Article
em En
| MEDLINE
| ID: mdl-3025633
ABSTRACT
The effect of the cell-specific mouse immunoglobulin heavy-chain gene (IgH) enhancer on transcription from heterologous promoter elements was studied in vitro with a HeLa whole-cell extract. No stimulation of transcription could be seen under conditions in which an activation was observed with the simian virus 40 enhancer. We found, however, that a specific segment of the IgH enhancer region contains sequences which inhibit transcription in vitro.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Genes Reguladores
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Elementos Facilitadores Genéticos
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Cadeias Pesadas de Imunoglobulinas
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Genes
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article