[SOME PARAMETERS OF THE IMMUNE STATE OF PATIENTS WITH DIABETIC FOOT SYNDROME AND SEPSIS].

The analysis of changes in the specific immunity in patients with purulent­necrotic complications of diabetic foot syndrome (DFS) and sepsis was presented. Complicated DFS was diagnosed in 436 patients, of whom 29 (6.6%) ­ weighed down by sepsis. The concentration of the major classes of immunoglobulins IgA, IgM, IgG were determined by enzyme­linked immunosorbent assay (ELISA). To evaluate the immune state was determined lymphocyte subpopulations (CD4+, CD3+, CD8+, CD25+) with monoclonal antibodies to antigens use by flow cytometry. It was found that in patients with DFS indicators specific cellular immunity were in a state of suppression, which deepened at complication of sepsis. Based on the derived formula with DFS marked disorders of the immune system I degree, in sepsis ­ II degree. Thus, the cellular and humoral immune system in patients with both DFS and sepsis qualified as a general immune depression.