Outcome of two patients with bilateral nephroblastomatosis/Wilms tumour treated with an add-on 13-cis retinoic acid therapy - Case report.
Pediatr Hematol Oncol
; 35(3): 218-224, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-30260265
ABSTRACT
Although the fate of nephrogenic rests varies, they are known to be precursors of Wilms tumour. Thus, nephrogenic rests require adequate treatment to prevent malignant transformation. We added 13-cis retinoic acid to the standard chemotherapy with vincristine and actinomycin-D in two patients with bilateral nephrogenic rests/nephroblastomatosis. Patient 1 also had a history of Wilms tumour. 46 (patient 1) and 81 (patient 2) months after end of treatment, both patients show stable conditions with no signs of relapse or progressive disease. Our observation supports further investigation of retinoic acid in patients with nephrogenic rests and nephroblastomatosis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Isotretinoína
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Protocolos de Quimioterapia Combinada Antineoplásica
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Tumor de Wilms
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Neoplasias Renais
Tipo de estudo:
Prognostic_studies
Limite:
Child, preschool
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Female
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Humans
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Infant
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article