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Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants.
Timmers, Maarten; Ravenstijn, Paulien; Xi, Liwen; Triana-Baltzer, Gallen; Furey, Maura; Van Hemelryck, Sandy; Biewenga, Jeike; Ceusters, Marc; Bhattacharya, Anindya; van den Boer, Maarten; van Nueten, Luc; de Boer, Peter.
Afiliação
  • Timmers M; 1 Janssen Research and Development, Beerse, Belgium.
  • Ravenstijn P; 2 Reference Centre for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium.
  • Xi L; 1 Janssen Research and Development, Beerse, Belgium.
  • Triana-Baltzer G; 3 Janssen Research and Development, Malvern, PA, USA.
  • Furey M; 4 Janssen Research and Development, San Diego, CA, USA.
  • Van Hemelryck S; 4 Janssen Research and Development, San Diego, CA, USA.
  • Biewenga J; 1 Janssen Research and Development, Beerse, Belgium.
  • Ceusters M; 1 Janssen Research and Development, Beerse, Belgium.
  • Bhattacharya A; 1 Janssen Research and Development, Beerse, Belgium.
  • van den Boer M; 4 Janssen Research and Development, San Diego, CA, USA.
  • van Nueten L; 1 Janssen Research and Development, Beerse, Belgium.
  • de Boer P; 1 Janssen Research and Development, Beerse, Belgium.
J Psychopharmacol ; 32(12): 1341-1350, 2018 12.
Article em En | MEDLINE | ID: mdl-30260294
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Triazóis / Encéfalo / Interleucina-1beta / Antagonistas do Receptor Purinérgico P2X Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Triazóis / Encéfalo / Interleucina-1beta / Antagonistas do Receptor Purinérgico P2X Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article