The isolation, absolute configuration and activities of 18(4â¯ââ¯3)-abeo-abietane lactones from Tripterygium wilfordii.
Bioorg Chem
; 82: 68-73, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30268975
ABSTRACT
Phytochemical studies on the leaves of Tripterygium wilfordii led to the isolation of seven new 18(4â¯ââ¯3)-abeo-abietane lactones, triptergulides E - K (1 - 7). The structure of the new compounds was elucidated on the basis of their spectroscopic analysis, and the absolute configurations of compounds were confirmed by ECD, calculated ECD, and X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Some compounds showed moderate inhibitory activities against NO, IL-6, and TNF-α production in LPS RAW 264.7 macrophage in vitro.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tripterygium
/
Abietanos
/
Lactonas
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article