Extensively drug-resistant (XDR) Pseudomonas aeruginosa identified in Lima, Peru co-expressing a VIM-2 metallo-ß-lactamase, OXA-1 ß-lactamase and GES-1 extended-spectrum ß-lactamase.
JMM Case Rep
; 5(7): e005154, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-30275958
ABSTRACT
INTRODUCTION:
Pseudomonas aeruginosa has the ability to acquire plasmids and other mobile genetic elements that confer resistance to antibiotics. Bacterial genes encoding different ß-lactamases (bla), such as metallo-ß-lactamases (MBLs) and extended-spectrum ß-lactamases (ESBL), can confer resistance to multiple classes of ß-lactam antibiotics. CASE PRESENTATION An 83 year old female was admitted in 2012 to the Peruvian Naval Hospital, Centro Médico Naval 'Cirujano Mayor Santiago Távara' (CEMENA), in Lima, Peru. A midstream urine sample was collected and sent to the local CEMENA laboratory for routine urine culture. P. aeruginosa was isolated and initial antibiotic susceptibility testing showed it to be sensitive to imipenem. The clinicians started a course of meropenem, but the patient did not improve. After 5 days, a second urine culture was performed and a P. aeruginosa was isolated again, but this time the strain showed resistance to imipenem. The treatment course was changed to fosfomycin and the patient improved. Phenotypic and molecular laboratory testing to characterize the antibiotic resistance were performed, demonstrating the presence of both MBL and ESBL genes.CONCLUSION:
To our knowledge, this is the first report of a P. aeruginosa XDR clinical isolate that co-expresses an MBL (VIM-2), OXA-1 beta-lactamase and the ESBL (GES-1) in Peru. It is also the first report of a VIM carbapenemase in Peru.
Texto completo:
1
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
País como assunto:
America do sul
/
Peru
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article