Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice.

Ouweneel, Amber B; Hoekstra, Menno; van der Wel, Ezra J; Schaftenaar, Frank H; Snip, Olga S C; Hassan, Jasmin; Korporaal, Suzanne J A; Van Eck, Miranda

Ouweneel, Amber B; Hoekstra, Menno; van der Wel, Ezra J; Schaftenaar, Frank H; Snip, Olga S C; Hassan, Jasmin; Korporaal, Suzanne J A; Van Eck, Miranda.

Afiliação

Ouweneel AB; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. Electronic address: a.b.ouweneel@lacdr.leidenuniv.nl.
Hoekstra M; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
van der Wel EJ; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
Schaftenaar FH; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
Snip OSC; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
Hassan J; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
Korporaal SJA; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Van Eck M; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.

Atherosclerosis ; 282: 176-182, 2019 03.

Article em En | MEDLINE | ID: mdl-30278990

Assuntos

Plaquetas/metabolismo; Colesterol/sangue; Hipercolesterolemia/genética; Megacariócitos/metabolismo; Receptores Depuradores Classe B/genética; Animais; Medula Óssea/metabolismo; Células da Medula Óssea/citologia; Células da Medula Óssea/metabolismo; Colesterol/metabolismo; Feminino; Hiperlipidemias/metabolismo; Megacariócitos/citologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Fenótipo; Trombocitopenia; Trombopoese

Palavras-chave

HDL; Megakaryocytes; Scavenger receptor BI; Thrombopoiesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plaquetas / Megacariócitos / Colesterol / Receptores Depuradores Classe B / Hipercolesterolemia Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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