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The complete genome sequence analysis of West Nile virus strains isolated in Slovakia (central Europe).
Drzewnioková, Petra; Barzon, Luisa; Franchin, Elisa; Lavezzo, Enrico; Bakonyi, Tamás; Pistl, Juraj; Csank, Tomás.
Afiliação
  • Drzewnioková P; Department of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Kosice, Kosice, Slovakia.
  • Barzon L; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Franchin E; Microbiology and Virology Unit, Padova University Hospital, Padova, Italy.
  • Lavezzo E; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Bakonyi T; Microbiology and Virology Unit, Padova University Hospital, Padova, Italy.
  • Pistl J; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Csank T; Institute of Virology, University of Veterinary Medicine Vienna, Vienna, Austria.
Arch Virol ; 164(1): 273-277, 2019 Jan.
Article em En | MEDLINE | ID: mdl-30284630
The present study reports the first complete genome sequence analysis of West Nile virus (WNV) strains isolated from brain samples from raptors. The results prove the circulation of closely related WNV lineage II strains in central Europe and genetic analysis revealed seven amino acid substitutions in structural (PrM3, E159 and E231) and in non-structural (NS1109, NS5259, NS5310 and NS5600) proteins. Observed amino acid substitutions Phe3 and Ser231 were common only within the lineage VII Koutango strain isolated from Rhipicephalus guilhoni tick in Senegal. Further research could reveal whether these substitutions influence the biological properties of WNV, including virulence and neuroinvasiveness.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus do Nilo Ocidental / Genoma Viral Limite: Animals País como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus do Nilo Ocidental / Genoma Viral Limite: Animals País como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article