New Recipes for Myelinating Oligodendrocytes.

Nobuta, Hiroko; Stockley, John H; Rowitch, David H

Nobuta, Hiroko; Stockley, John H; Rowitch, David H.

Afiliação

Nobuta H; Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Departments of Pediatrics and Neurosurgery, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA.
Stockley JH; Department of Paediatrics, Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0QQ, UK.
Rowitch DH; Departments of Pediatrics and Neurosurgery, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA; Department of Paediatrics, Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, CB2 0QQ, UK. Electronic address: dhr25@medschl.cam.ac.uk.

Cell Stem Cell ; 23(4): 464-465, 2018 10 04.

Article em En | MEDLINE | ID: mdl-30290175

ABSTRACT

ABSTRACT

While myelinating oligodendrocytes are attractive candidates for cell-based regenerative therapies, producing them in adequate quantities and regulation of progenitor differentiation pathways has proven limiting. Recently, Hubler et al. (2018) and Madhavan et al. (2018) generated cerebral organoids with myelinating oligodendrocytes and manipulated sterol pathway small molecules to promote myelin synthesis.

Assuntos

Bainha de Mielina; Oligodendroglia; Diferenciação Celular; Humanos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligodendroglia / Bainha de Mielina Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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