Isoliquiritigenin protects against blood­brain barrier damage and inhibits the secretion of pro-inflammatory cytokines in mice after traumatic brain injury.

Zhang, Man; Wu, Yanqing; Xie, Ling; Teng, Chen-Huai; Wu, Fang-Fang; Xu, Ke-Bin; Chen, Xiong; Xiao, Jian; Zhang, Hong-Yu; Chen, Da-Qing

Isoliquiritigenin protects against bloodbrain barrier damage and inhibits the secretion of pro-inflammatory cytokines in mice after traumatic brain injury.

Zhang, Man; Wu, Yanqing; Xie, Ling; Teng, Chen-Huai; Wu, Fang-Fang; Xu, Ke-Bin; Chen, Xiong; Xiao, Jian; Zhang, Hong-Yu; Chen, Da-Qing.

Afiliação

Zhang M; Department of Emergency, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wu Y; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China; The Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China.
Xie L; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Teng CH; Department of Emergency, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wu FF; Department of Emergency, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xu KB; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Chen X; Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xiao J; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhang HY; Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: hyzhang@wmu.edu.cn.
Chen DQ; Department of Emergency, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: cdq1965@126.com.

Int Immunopharmacol ; 65: 64-75, 2018 Dec.

Article em En | MEDLINE | ID: mdl-30290368

Assuntos

Barreira Hematoencefálica/efeitos dos fármacos; Lesões Encefálicas Traumáticas/tratamento farmacológico; Chalconas/farmacologia; Citocinas/metabolismo; Regulação da Expressão Gênica/efeitos dos fármacos; Animais; Lesões Encefálicas Traumáticas/imunologia; Linhagem Celular; Linhagem Celular Tumoral; Citocinas/antagonistas & inibidores; Citocinas/genética; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL

Palavras-chave

Blood-brain barrier (BBB); Inflammation; Isoliquiritigenin; PI3K/AKT/GSK3ß/NFκB signalling pathway; Traumatic brain injury (TBI)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Regulação da Expressão Gênica / Citocinas / Chalconas / Lesões Encefálicas Traumáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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