Phagocytosis and ROS production as biomarkers in Nile tilapia (Oreochromis niloticus) leukocytes by exposure to organophosphorus pesticides.
Fish Shellfish Immunol
; 84: 189-195, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30291982
ABSTRACT
Organophosphorus pesticides (OPs) are broad-spectrum insecticides. One of the commonly used OPs is diazinon (DZN). The aim of this study was to evaluate the immunotoxic effect of DZN on phagocytic parameters of blood leukocytes using the teleost fish Oreochromis niloticus as a study model. For this purpose, fish were exposed in vivo to 0.97, 1.95 and 3.97â¯mg/L of DZN for 6 and 24â¯h. Our results indicated that phagocytic active cells decreased in fish exposed in vivo to 0.97 and 1.95â¯mg/L of DZN for 6 and 24â¯h. Regarding ROS production, H2O2 and O2- levels were higher on fish exposed to 1.95â¯mg/L for 6 and 24â¯h, while H2O2 production increased at 0.97â¯mg/L for 24â¯h. From this we can conclude that phagocytic parameters are sensitive to assess the effect of acute intoxication with organophosphorus pesticides on Nile tilapia.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fagocitose
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Explosão Respiratória
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Espécies Reativas de Oxigênio
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Ciclídeos
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Diazinon
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Inseticidas
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Leucócitos
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article