Diversity of Quaternary Structures Regulates Nuclear Receptor Activities.
Trends Biochem Sci
; 44(1): 2-6, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30293659
ABSTRACT
Nuclear receptors (NRs) form homo- and/or heterodimers as central scaffolds of multiprotein complexes, which activate or repress gene transcription to regulate development, homeostasis, and metabolism. Recent studies on NR quaternary structure reveal novel mechanisms of receptor dimerization, the existence of tetrameric chromatin-bound NRs, and previously unanticipated protein-protein/protein-DNA interactions.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores Citoplasmáticos e Nucleares
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article