The EVcouplings Python framework for coevolutionary sequence analysis.
Bioinformatics
; 35(9): 1582-1584, 2019 05 01.
Article
em En
| MEDLINE
| ID: mdl-30304492
ABSTRACT
SUMMARY:
Coevolutionary sequence analysis has become a commonly used technique for de novo prediction of the structure and function of proteins, RNA, and protein complexes. We present the EVcouplings framework, a fully integrated open-source application and Python package for coevolutionary analysis. The framework enables generation of sequence alignments, calculation and evaluation of evolutionary couplings (ECs), and de novo prediction of structure and mutation effects. The combination of an easy to use, flexible command line interface and an underlying modular Python package makes the full power of coevolutionary analyses available to entry-level and advanced users. AVAILABILITY AND IMPLEMENTATION https//github.com/debbiemarkslab/evcouplings.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Software
/
Análise de Sequência
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article