X-box binding protein l splicing attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through the activation of phosphoinositide 3-kinase/protein kinase B, extracellular signal-regulated kinases, and hypoxia-inducible factor-1&#945;/vascular endothelial growth factor signaling pathways.

Shi, Shupeng; Tang, Mimi; Li, Honglei; Ding, Hui; Lu, Yangfan; Gao, Lijuan; Wu, Qian; Zhou, Luo; Fu, Yujiao; Xiao, Bo; Zhang, Mengqi

X-box binding protein l splicing attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through the activation of phosphoinositide 3-kinase/protein kinase B, extracellular signal-regulated kinases, and hypoxia-inducible factor-1α/vascular endothelial growth factor signaling pathways.

Shi, Shupeng; Tang, Mimi; Li, Honglei; Ding, Hui; Lu, Yangfan; Gao, Lijuan; Wu, Qian; Zhou, Luo; Fu, Yujiao; Xiao, Bo; Zhang, Mengqi.

Afiliação

Shi S; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Tang M; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
Li H; Institute of Hospital Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
Ding H; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Lu Y; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Gao L; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Wu Q; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Zhou L; Department of Neurology, First Affiliated Hospital, Kunming Medical University, Kunming, China.
Fu Y; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xiao B; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Zhang M; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

J Cell Physiol ; 234(6): 9316-9327, 2019 06.

Article em En | MEDLINE | ID: mdl-30317635

Assuntos

Encéfalo/patologia; Células Endoteliais/patologia; Glucose/deficiência; Microvasos/patologia; Oxigênio/metabolismo; Splicing de RNA/genética; Transdução de Sinais; Proteína 1 de Ligação a X-Box/genética; Animais; Apoptose; Ciclo Celular; Movimento Celular; Sobrevivência Celular; Células Endoteliais/efeitos dos fármacos; Células Endoteliais/metabolismo; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Neovascularização Fisiológica; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos Sprague-Dawley; Fator A de Crescimento do Endotélio Vascular/metabolismo; Proteína 1 de Ligação a X-Box/metabolismo

Palavras-chave

X-box binding protein l splicing (XBP1s); angiogenesis; brain microvascular endothelial cells (BMECs); ischemic stroke

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Encéfalo / Transdução de Sinais / Splicing de RNA / Células Endoteliais / Microvasos / Proteína 1 de Ligação a X-Box / Glucose Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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