CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization.

Wang, Haifeng; Xu, Xiaoshu; Nguyen, Cindy M; Liu, Yanxia; Gao, Yuchen; Lin, Xueqiu; Daley, Timothy; Kipniss, Nathan H; La Russa, Marie; Qi, Lei S

Wang, Haifeng; Xu, Xiaoshu; Nguyen, Cindy M; Liu, Yanxia; Gao, Yuchen; Lin, Xueqiu; Daley, Timothy; Kipniss, Nathan H; La Russa, Marie; Qi, Lei S.

Afiliação

Wang H; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Xu X; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Nguyen CM; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Liu Y; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Gao Y; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Cancer Biology Program, Stanford University, Stanford, CA 94305, USA.
Lin X; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Daley T; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Statistics, Stanford University, Stanford, CA 94305, USA.
Kipniss NH; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
La Russa M; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Qi LS; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA; Stanford ChEM-H, Stanford University, Stanford, CA 94305, USA. Electronic address: stanley.qi@stanford.edu.

Cell ; 175(5): 1405-1417.e14, 2018 11 15.

Article em En | MEDLINE | ID: mdl-30318144

Assuntos

Sistemas CRISPR-Cas/genética; Edição de Genes/métodos; Genoma; Ácido Abscísico/farmacologia; Linhagem Celular Tumoral; Cromatina/genética; Cromatina/metabolismo; Corpos Enovelados/genética; Regulação da Expressão Gênica; Loci Gênicos; Humanos; Hibridização in Situ Fluorescente; Pontos de Checagem da Fase S do Ciclo Celular/efeitos dos fármacos

Palavras-chave

3D genome; CRISPR; CRISPR-GO; Cajal body; Cas9; PML body; gene regulation; gene repression; nuclear body; nuclear periphery

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genoma / Sistemas CRISPR-Cas / Edição de Genes Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google