Statins and Incidence of Contrast-Induced Acute Kidney Injury Following Coronary Angiography - Five Year Experience at a Tertiary Care Center.
Cardiovasc Revasc Med
; 20(8): 654-658, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-30318173
ABSTRACT
BACKGROUND:
Role of statins in prevention of contrast-induced acute kidney injury (CI-AKI) in patients undergoing coronary angiography remains controversial. We studied the use of statins in decreasing CI-AKI following coronary angiography.METHODS:
We reviewed all patients who underwent coronary angiography with or without PCI and had a follow-up creatinine from January 2012 to December 2016 at a single tertiary care center in the United States. CI-AKI was defined as 0.3â¯mg/dL absolute rise in creatinine. Patients who were on moderate to high-intensity statins or received moderate to high-intensity statins prior to coronary angiography were included in the statin group. Crude and adjusted odds ratios (AOR) were calculated using univariate multiple logistic regression analysis.RESULTS:
Out of 2055 patients (femalesâ¯=â¯30.7%, mean age 58.0⯱â¯12.5â¯years, statin groupâ¯=â¯886, non-statin groupâ¯=â¯1169), 293 (14.3%) developed CI-AKI. Mean estimated glomerular filtration rate (eGFR) was not significantly different between the statin and the non-statin group (86.5â¯mL/min/1.73â¯m2 vs 87.1â¯mL/min/1.73â¯m2, pâ¯=â¯0.65). There was no significant difference in the incidence of CI-AKI between statin and non-statin group (14.4% vs 14.1%, pâ¯=â¯0.83). When adjusted for other risk factors, statin use was not significantly associated with decreased risk of CI-AKI (AOR)â¯=â¯0.8, [95% confidence interval (CI)â¯=â¯0.6-1.1, pâ¯=â¯0.19]. Results remained statistically non-significant on subgroup analysis of patients with acute coronary syndrome (ACS) (ORâ¯=â¯0.8, 95% CIâ¯=â¯0.6-1.2, pâ¯=â¯0.27), patients who had percutaneous coronary intervention (PCI) (ORâ¯=â¯1.1, 95% CIâ¯=â¯0.6-1.7, pâ¯=â¯0.81) and patients with eGFRâ¯<â¯60â¯mL/min/1.73â¯m2 (ORâ¯=â¯0.9, 95% CIâ¯=â¯0.6-1.5, pâ¯=â¯0.9).CONCLUSION:
Statin use prior to coronary angiography is not associated with decreased incidence of CI-AKI.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
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Angiografia Coronária
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Inibidores de Hidroximetilglutaril-CoA Redutases
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Meios de Contraste
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Síndrome Coronariana Aguda
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Injúria Renal Aguda
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Centros de Atenção Terciária
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article