A multipronged approach unravels unprecedented protein-protein interactions in the human 2-oxoglutarate dehydrogenase multienzyme complex.

Zhou, Jieyu; Yang, Luying; Ozohanics, Oliver; Zhang, Xu; Wang, Junjie; Ambrus, Attila; Arjunan, Palaniappa; Brukh, Roman; Nemeria, Natalia S; Furey, William; Jordan, Frank

Zhou, Jieyu; Yang, Luying; Ozohanics, Oliver; Zhang, Xu; Wang, Junjie; Ambrus, Attila; Arjunan, Palaniappa; Brukh, Roman; Nemeria, Natalia S; Furey, William; Jordan, Frank.

Afiliação

Zhou J; From the Department of Chemistry, Rutgers, The State University of New Jersey, Newark, New Jersey 07102.
Yang L; From the Department of Chemistry, Rutgers, The State University of New Jersey, Newark, New Jersey 07102.
Ozohanics O; the Department of Medical Biochemistry, MTA-SE Laboratory for Neurobiochemistry, Semmelweis University, 27-29 Tuzolto Utca, Budapest H-1094, Hungary.
Zhang X; From the Department of Chemistry, Rutgers, The State University of New Jersey, Newark, New Jersey 07102.
Wang J; From the Department of Chemistry, Rutgers, The State University of New Jersey, Newark, New Jersey 07102.
Ambrus A; the Department of Medical Biochemistry, MTA-SE Laboratory for Neurobiochemistry, Semmelweis University, 27-29 Tuzolto Utca, Budapest H-1094, Hungary.
Arjunan P; the Biocrystallography Laboratory, Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240.
Brukh R; the Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, and.
Nemeria NS; From the Department of Chemistry, Rutgers, The State University of New Jersey, Newark, New Jersey 07102.
Furey W; From the Department of Chemistry, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, nemeria@newark.rutgers.edu.
Jordan F; the Biocrystallography Laboratory, Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240.

J Biol Chem ; 293(50): 19213-19227, 2018 12 14.

Article em En | MEDLINE | ID: mdl-30323066

Assuntos

Complexo Cetoglutarato Desidrogenase/metabolismo; Mapeamento de Interação de Proteínas/métodos; Sequência de Aminoácidos; Sítios de Ligação; Humanos; Complexo Cetoglutarato Desidrogenase/química; Espectrometria de Massas; Modelos Moleculares; Conformação Proteica em alfa-Hélice

Palavras-chave

chemical cross-linking MS; dehydrogenase; human 2-oxoglutarate dehydrogenase complex; hydrogen exchange mass spectrometry; isothermal titration calorimetry (ITC); mass spectrometry (MS); neurodegeneration, oxidative stress; protein complex interaction loci; site-selected fluorescent labeling; tricarboxylic acid cycle (TCA cycle) (Krebs cycle)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mapeamento de Interação de Proteínas / Complexo Cetoglutarato Desidrogenase Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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