Upper-Rim Monofunctionalisation in the Synthesis of Triazole- and Disulfide-Linked Multicalix[4]- and -[6]arenes.
Chemistry
; 24(71): 19089-19097, 2018 Dec 17.
Article
em En
| MEDLINE
| ID: mdl-30325070
ABSTRACT
Covalently linked multiple calixarenes are valued in supramolecular chemistry. This work reports an easy and versatile synthetic route to covalently linked double and triple calix[4]arene and calix[6]arenes by a novel DMF-controlled selective alkylation of a convenient and readily available upper-rim dimethylaminomethyl-substituted tetrahydroxy and hexahydroxy calix[4]arene and -[6]arenes. Synthetic routes to upper-rim functionalised redox active disulfide-linked double-, tetra- and peptidohybrid-calixarenes employing either redox chemistry (CH2 SH) or thiolates (CH2 S- ) are also opened up from the same key starting material.
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MEDLINE
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En
Ano de publicação:
2018
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Article