INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study.
Immunotherapy
; 10(14): 1229-1239, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30326787
ABSTRACT
AIM:
Considering the unmet need for the counseling of cancer patients treated with immune checkpoint inhibitors (CKI) about influenza vaccination, an explorative study was planned to assess flu vaccine efficacy in this population.METHODS:
INVIDIa was a retrospective, multicenter study, enrolling consecutive advanced cancer outpatients receiving CKI during the influenza season 2016-2017.RESULTS:
Of 300 patients, 79 received flu vaccine. The incidence of influenza syndrome was 24.1% among vaccinated, versus 11.8% of controls; odds ratio 2.4; 95% CI 1.23-4.59; p = 0.009. The clinical ineffectiveness of vaccine was more pronounced among elderly 37.8% among vaccinated patients, versus 6.1% of unvaccinated, odds ratio 9.28; 95% CI 2.77-31.14; p < 0.0001.CONCLUSION:
Although influenza vaccine may be clinically ineffective in advanced cancer patients receiving CKI, it seems not to negatively impact the efficacy of anticancer therapy.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
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Vacinas contra Influenza
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Influenza Humana
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Imunoterapia
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Anticorpos Monoclonais
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Neoplasias
Tipo de estudo:
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article