Congenital cytomegalovirus infection via a re-infected mother with original antigenic sin: A case report.
Int J Infect Dis
; 77: 87-89, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-30339986
ABSTRACT
A 27-year-old pregnant woman who was positive for anti-cytomegalovirus (CMV) antibodies gave birth to a congenitally CMV-infected neonate at 40 weeks of gestation. According to strain-specific serological analysis, which is able to determine the two types of CMV glycoprotein H (gH), the mother possessed anti-gH(To) antibodies only, but the neonate possessed anti-gH(AD) and anti-gH(To) antibodies at 4 weeks after birth. As the anti-gH(To) IgG was decreased in the neonate at 8 months post-delivery, these antibodies are thought to have been transferred from the mother as maternal antibodies. The anti-gH(AD) IgG level was maintained in the child even after 8 months post-delivery. Congenital infection with a CMV gH(AD) type strain was confirmed by strain-specific real-time PCR using a urine specimen from the child. On the other hand, anti-gH(AD) IgG was not detected even after 8 months post-delivery in a maternal specimen. The mother only produced antibodies against the CMV strain identified as the primary infection, which is characteristic of original antigenic sin.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
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Infecções por Citomegalovirus
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Transmissão Vertical de Doenças Infecciosas
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Anticorpos Antivirais
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Infant
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Pregnancy
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article