The role of sphingosine 1 phosphate in coronary artery disease and ischemia reperfusion injury.
J Cell Physiol
; 234(3): 2083-2094, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30341893
ABSTRACT
Coronary artery disease (CAD) is a common cause of morbidity and mortality worldwide. Atherosclerotic plaques, as a hallmark of CAD, cause chronic narrowing of coronary arteries over time and could also result in acute myocardial infarction (AMI). The standard treatments for ameliorating AMI are reperfusion strategies, which paradoxically result in ischemic reperfusion (I/R) injury. Sphingosine 1 phosphate (S1P), as a potent lysophospholipid, plays an important role in various organs, including immune and cardiovascular systems. In addition, high-density lipoprotein, as a negative predictor of atherosclerosis and CAD, is a major carrier of S1P in blood circulation. S1P mediates its effects through binding to specific G protein-coupled receptors, and its signaling contributes to a variety of responses, including cardiac inflammation, dysfunction, and I/R injury protection. In this review, we will focus on the role of S1P in CAD and I/R injury as a potential therapeutic target.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esfingosina
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Doença da Artéria Coronariana
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Lisofosfolipídeos
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Traumatismo por Reperfusão
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Aterosclerose
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article